Neisseria gonorrhoeae and Neisseria meningitidis are both Gram Negative Bacteria. They are diplococci, non-sporing, non-motile and oxidase positive. But they have some differences which are as follows:
|1||Referred as||Referred to as gonococcus.||Referred to as meningococcus.|
|2||Agents||N. gonorrhoeae is the agent of gonorrhoea.||N. meningitidis is a major cause of cerebrospinal meningitis.|
|3||Vaccine Development||No||Serogroup A, B, C, Y and W-135 meningococcal infections can be prevented by vaccines.|
|4||Colony Morphology||N. gonorrhoeae form smooth, round, moist, uniform
grey/brown colonies with a greenish colour underneath on primary isolation medium.
|N. meningitides would form smooth, round, moist, uniform
large grey/brown colonies with a glistening surface and entire edges.
|5||Morphology||N. gonorrhoea is kidney shaped with apposing ends concave.||N. meningitidis is semicircular diplococcus with flat apposing ends.|
|8||Nitrite Reduction||N. gonorrhoeae doesn’t reduce nitrites.||N. meningitidis can reduce nitrites in low concentrations.|
|9||Growth on Blood Agar||N. gonorrhoeae grow less
well on blood agar than N. meningitidis.
|N. meningitidis grow well on blood agar than N. gonorrhoeae.|
|10||Capsule||No||Yes. The capsule is anti-phagocytic and is an important virulence factor.|
|11||Site of Infection||Primarily causing infection of the anogenital tract.||Colonizes the upper respiratory tract as a commensal and occasionally invades to
cause systemic disease.
|12||Pathogens||It is always considered a pathogen.||It is not always considered as pathogens.|
|13||Enzyme Production||It doesn’t produce gamma-glutamylaminotransferase.||It produces gamma-glutamylaminotransferase.|
|14||Specimen Collection||Transport swab of endocervix, urethra, rectum, pharynx, conjunctiva, blood, joint fluid, aspirates from skin lesions.||Collect cerebrospinal fluid (CSF) and blood, swab skin lesions and nasopharynx.|
|16||Movement||Movement of N. gonorrhoeae occurs at lower speed.||Movement of N. meningitidis occurred at higher speed and with a larger number of retracting pili.|
|17||Pili||N. gonorrhoeae most often moved using one retracting pilus.||N. meningitidis most often used four pili.|
|18||Prevalence and Mortality||N. gonorrhoeae infections have a high prevalence and low mortality||N. meningitidis infections have a low prevalence and high mortality.|
|19||Superbug||Considered as “superbug”||Not considered as “superbug”|
|20||Pathogenesis||N. gonorrhoeae can also cause conjunctivitis, pharyngitis, proctitis or urethritis, prostatitis, and orchitis.||Cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening sepsis.|