Good Laboratory Practices (GLP) is an official regulation that was created by the FDA in 1978. Good Laboratory Practice (GLP) is a quality system concerned with the organizational process and the conditions under which non-clinical health and environmental safety studies are planned, performed, monitored, recorded, … Read more
C-Reactive Protein (CRP), also known as Pentraxin 1, is a non-glycosylated protein in the Pentraxin family that also includes Pentraxin 2/SAP and Pentraxin 3/TSG-14. CRP is an acute phase reactant, a protein made by the liver and released into the blood within a few hours after … Read more
Coombs test is also known as antiglobulin test. The Coombs test tests for antibodies that may stick to the red blood cells and cause red blood cells to die too early. It was discovered by Coombs, Mourant and Race in 1945. Coombs reagent is antihuman … Read more
Hemolysis is the breakdown of red blood cells (RBC). A substance that causes hemolysis is a hemolysin. Brown (1919) introduced three terms alpha, beta and gamma to indicate three types of streptococci based on haemolytic reactions observed on blood agar plates. Beta-hemolytic Streptococci Beta-hemolysis (β-hemolysis) is … Read more
Polymerase Chain Reaction (PCR) is a powerful method for amplifying particular segments of DNA, distinct from cloning and propagation within the host cell. This procedure is carried out entirely biochemically, that is, in vitro. PCR was invented by Kary Mullis in 1983. He shared the Nobel Prize … Read more
Normal Laboratory Values: Blood, Plasma, and Serum Test Specimen Conventional Units SI Units Acetoacetate Plasma < 1 mg/dL < 0.1 mmol/L Acetylcholinesterase (ACE), RBC Blood 26.7–49.2 U/g Hb — Acid phosphatase Serum 0.5–5.5 U/L 0–0.9 μkat/L Activated partial thromboplastin time (aPTT) Plasma 25–35 sec — … Read more
Uric acid crystals invariably form in acidic urine, typically with a urine pH < 5.5. Uric acid is soluble in alkaline urine, preventing the precipitation of urate crystals. The inability of uric acid to crystallize at urine pH > 7.0 is the rationale for urinary alkalinization in patients at … Read more