Although mature lymphocytes all look pretty much alike, they are extraordinarily diverse in their functions. The most abundant lymphocytes are:
B lymphocytes (often simply called B cells) and
T lymphocytes (likewise called T cells).
Some of the differences between B Cells and T Cells are as follows:
|1||Name||B lymphocytes||T lymphocytes|
|3||Position||Outside Lymph Node||Interior of Lymph Node|
|BCR (= immunoglobulin) for antigen||TCR for antigen|
|5||Connections||B-cells can connect to antigens right on the surface of the invading virus or bacteria.||T-cells can only connect to virus antigens on the outside of infected cells.|
|6||Tissue Distribution||Germinal centres of lymph nodes, spleen, gut, respiratory tract; also subcapsular and medullary cords of lymph nodes|
Parafollicular areas of cortex in
nodes, periarteriolar in spleen
|7||Life Span||Life span is short||Life span is long|
|8||Surface Antibodies||Surface Antibodies present||Absence of surface antibodies|
|9||Secretion||They secrete antibodies||They secrete Lymphokines|
|10||Function||В-cells form humoral or antibody-mediated immune system (AMI).||T-cells form cell-mediated immune system (CMI).|
|11||Blood||20% of lymphocytes||80% of lymphocytes; CD4 > CD8|
|12||Formation||They form plasma cells and memory cells.||They form killer, helper and suppressor cells.|
|13||Movement to Infection Site||Plasma cells do not move to the site of infection.||Lymphoblasts move to the site of infection.|
|14||Function||Plasma cells do not react against transplants and cancer cells.||Killer cells react against transplants and cancer cells.|
|15||Function||Plasma cells have no inhibitory effect on immune system.||Suppressor cells inhibit immune system.|
|16||Function||They defend against viruses and bacteria that enter the blood and lymph.||They defend against pathogens including protists and fungi that enter the cells.|
9 thoughts on “Differences Between B-Cells and T-Cells”
All tha t-cells have CD3 receptor on their surface .
T suppressor(CD8)cells :
T-cells block immune response by their action on t-helper cells on b-cells
Cytotoxic t(tc) cells
Regulatory t-cells Effector t-cells
1. CD4 1.cytotoxic t-cell
question: how do the t-cells and b-cells react differently from infection of a virus directly versus infection via vaccine?
Good work.But i got a small rectification on ORIGIN,both B and T lymphocytes originate from bonemarrow[red] but they mature in different organs:bonemarrow and thymus respectively.
Thank you. I work in the field of bleeding disorders. As an Hemophilia and Thrombophilia Treatment Center social worker, I constantly look for educational materials for my patients and their families.
There is a mistake.. B cells are not formed in bone marrow, but in bursts (meaning pouches) eg. in appendix..
I am also intrusted in medical microbiology and virology…and I m learning many from u…many thanks
In the healthy male and female subjects, the mean concentration of Energy of cells, meaured in adenozine-triphosphat, ATP in 1 x 106 lymphocytes /ml of normal peripheral blood T lymphocytes, was 1.39 µM ATP and in B lymphocytes the concentration was 0.35 µM ATP/ml [SD = 0.41, p= 0.030].
From patients with malignant diseases, the concentration of ATP in 1 x 106 activated peripheral blood T lymphocytes/ml had a mean value of 3.06 µM ATP and the mean concentration of ATP in activated B lymphocytes/ml was 0.17 µM ATP [SD= 0.45, p = 0.05].
The mean concentration of ATP in 1 x 106 activated peripheral blood malignant CLL B lymphocytes/ml was 4.33 µM ATP but was only 0.09 µM ATP [SD= 1.5, p < 0.05] in T lymphocytes from these patients.
A strong correlation was observed between the concentration of ATP of T lymphocytes from patients withmalignant diseases and ATP concentration of B lymphocytes from samples of patients with CLL (r= 0.99) and a good correlation was observed between T lymphocytes (Th) from allergic diseases and T lymphocytes (Ts) from malignant diseases (r = 0.94).
The difference of energy between anaerobic ATP in B lymphocytes from CLL and aerobic ATP in T lymphocytes from healthy subjects havebeen calculated in value of 2.68 µM ATP, suggests the process of carcinogenesis, in malignant diseases.
hierarchy：B-cells are soldiers where T-cells include generals, commanders, officers and even military police.