Differences Between Staphylococcus and Streptococcus

Staphylococcus and Streptococcus are both Gram positive organisms and cocci in shape. They are Non-motile, Non-Sporing and Facultative anaerobes. But they possess some of the differences which are as follows:





1 Arrangement Grape-like clusters. A chain of round cells.
2 Division Staphylococci divide in various directions (multiple axes). Division occurs in one linear direction (single axis).
3 Catalase Test Positive (Catalase is an enzyme to  converts hydrogen peroxide to water and oxygen gas). Negative
4 Enriched Media Staph does not need enriched media (not fastidious). Strep needs enriched media (fastidious).
5 Habitat Staphylococci are found on the skin. Streptococci are found in the respiratory tract.
6 Hemolysis No hemolysis or beta hemolysis. Either alpha, or beta or gamma hemolysis.
7 Species Number About 40 staphylococcal species have been identified so far. About 50 Streptococcal species  have been identified so far.
8 Pathogenesis Most of the staphylococcal species are non-pathogens. Streptococcus cause many diseases.
9 Common Diseases Food poisoning,  bacterial conjunctivitis, skin diseases, community-acquired meningitis,  Surgical Site Infection, Wound infection,  impetigo, cellulitis, and toxic shock syndrome. Strep throat, Scarlet fever, Impetigo, Toxic shock syndrome,

Cellulitis and necrotizing fasciitis (flesh-eating disease), sinusitis,  blood infections, pneumonia and meningitis in newborns.

10 Pathogenic Species Staphylococcus aureus,

Staphylococcus epidermidis,

Staphylococcus haemolyticus,

Staphylococcus hominis,

Staphylococcus saprophyticus, etc.


Streptococcus pyogenes,

Streptococcus agalactiae,

Streptococcus bovis,

Streptococcus  pneumoniae, etc.

11 Species Differentiation


– Coagulase test

– Novobiocin sensitivity test

– Biochemical tests

– Type of hemolysis

– Cell wall carbohydrate group (A, B, C, etc)

– Bile Solubility Test

– CAMPT Test

– Optochin Sensitivity Test

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