Differences Between Antigen and Antibody

Antibodies, also called immunoglobulins, Y-shaped molecules are proteins manufactured by the body that help fight against foreign substances called antigens. Antigens are any substance that stimulates the immune system to produce antibodies. Antigens can be bacteria, viruses, or fungi that cause infection and disease. Following are some of the differences between Antigen and Antibody:




1 Generally proteins but can be lipids, carbohydrates or nucleic acids. Antibodies are proteins.
2 Triggers the formation of antibodies. Variable sites has the antigen binding domain.
3 There are three basic kinds of antigens. (Exogenous, Endogenous and Autoantigens) There are five basic kinds of antibodies. (Immunoglobulins M, G, E, D and A)
4 The region of the antigen that interacts with the antibodies is called epitopes. The variable region of the antibody that specially binds to an epitope is called paratope.
5 Cause disease or allergic reactions. Protects the body by immobilization or lysis of antigenic material.

6 thoughts on “Differences Between Antigen and Antibody”

  1. Antigens are the key to develop antibodies against specific infection or disease that caused by the antigen (foreign substance) itself.

  2. It’s right and their production comes about as a result of medications for instance patients administered with alpha-methyl dopa develop haemolytic anaemia due to the production of RBC auto-antibodies, but it’s also seen that the anemia resolves on stopping the use of this drug.

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